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You are using an best ndb online casino blog browser. Please upgrade your browser or activate Google Chrome Frame to improve your experience. We currently have four programs underway: Endoxifen is the most active metabolite ingredient of the Best ndb online casino blog drug tamoxifen, which has been used since its approval in for breast cancer survivors best ndb online casino blog prevent recurrence as well as the development of new cancer.

We are developing both oral and a topical formulation of endoxifen. In mid we completed a Phase 1 clinical study which was conducted by a leading Clinical Research Organization in Australia. The study was a placebo-controlled, repeat dose study of best ndb online casino blog healthy female volunteers. The objectives were to assess safety, tolerability and pharmacokinetics of both formulations of endoxifen over 28 days.

All objectives were successfully met in the topical arms of the study. The topical formulation of our proprietary endoxifen is being developed for women with a condition lightning online slots link free mammographic best ndb online casino blog density, or MBD, which has been shown in third-party studies to result in a higher risk of developing breast cancer.

To date, 30 U. Although oral tamoxifen has been shown to reduce MBD, the benefit-risk ratio is generally not acceptable to most physicians and their patients. In mid we completed a Phase 1, placebo-controlled study of our proprietary topical Endoxifen.

All objectives of that study were successfully met:. The data from the Phase 1 study demonstrate the suitability of topical Endoxifen for further clinical development.

We have initiated a Phase 2 study click at this page our topical endoxifen in women with MBD. The study will be conducted at Stockholm South General Hospital in Sweden and will be led by principal investigator Dr.

Per Hall, MD, Ph. The placebo-controlled, double-blinded study is expected to enroll up to subjects. The primary endpoint is MBD reduction, which will be measured after six and twelve months of dosing, as well as safety and tolerability.

Research indicates that low endoxifen levels in breast cancer patients taking oral tamoxifen correlate with a higher risk of recurrence and new cancer as compared to breast cancer patients with adequate endoxifen levels.

Subject to favorable results from our Phase 1 study, we are planning to begin a Phase 2 study of oral endoxifen for these patients who are refractory to tamoxifen. We are also evaluating endoxifen in the neo-adjuvant setting, meaning it would be use best ndb online casino blog treat breast cancer before surgery to remove the cancerous tumor.

We are developing our online reviews nz casino microcatheter technology to deliver therapeutics through the nipple directly to the site of the cancer. The goals of this delivery method are to increase the amount of the therapy getting to the targeted area while reducing see more side effects that would otherwise be caused by delivering the drug through the blood stream.

We believe our patented intraductal microcatheter technology may be useful in delivering a number of drugs directly to the breast tissue. The initial drug we are studying using our microcatheters is learn more here. Fulvestrant is FDA-approved for metastatic breast cancer.

It is administered as a monthly intramuscular injection of two injections, typically into the buttocks. We own one issued patent and several pending applications directed to the treatment of breast conditions, including cancer, by the intraductal administration of therapeutics, including fulvestrant.

We are currently conducting a Phase 2 study using our microcatheter technology to deliver fulvestrant at Montefiore Medical Center. This trial is a Phase 2 study best ndb online casino blog women with ductal carcinoma in situ DCIS or Stage 1 or 2 breast cancer invasive ductal carcinoma scheduled for mastectomy or lumpectomy within 30 to 45 days. This best ndb online casino blog is assessing the safety, tolerability, cellular activity and distribution of fulvestrant when delivered directly into breast milk ducts of these patients compared to those who receive the same drug by injection.

Of the 30 patients required for full enrollment, six will receive the standard intramuscular injection of fulvestrant and best ndb online casino blog will receive fulvestrant with our microcatheter device. The primary endpoint of the clinical trial is to compare the safety, tolerability and distribution of fulvestrant between the two routes of administration intramuscular injection or through online roulette gewinn system microcatheters.

The secondary endpoint of the study is to determine if there are changes in the expression of Ki67 as well as estrogen and progesterone receptors between a pre-fulvestrant biopsy and post-fulvestrant surgical specimens. Digital breast imaging before and after drug administration in both groups will also be performed to determine the effect of fulvestrant on any lesions best ndb online casino blog well as breast density of the participant. We plan to use our proprietary intraductal microcatheter technology to deliver CAR-T cells into the ducts of the breast for the potential targeted treatment of breast cancer.

We believe this method has several potential advantages: This program is in the research and development phase and has not been approved by the FDA article source any other regulatory body.

Pre-clinical studies, and clinical studies demonstrating safety and efficacy among other things, and regulatory approvals will be required before commercialization. Chin J Cancer Res. The T cells, which can then recognize and kill the cancer cells, are reintroduced into the patient using a microcatheter into the natural ducts of the breast. Typically, these receptors are used to graft the specificity of a monoclonal antibody onto a T cell, with transfer of their coding sequence facilitated by retroviral vectors.

The receptors are called chimeric because they are composed of parts from different sources. Endoxifen Endoxifen is the most active metabolite ingredient of the FDA-approved drug tamoxifen, which has been used since its approval in for breast cancer survivors to click the following article recurrence as well as the development of new cancer.

All objectives of that study were best ndb online casino blog met: Read more were no clinically significant safety signals best ndb online casino blog no clinically significant adverse events in participants receiving topical Endoxifen. Topical Endoxifen was well tolerated at each dose level and for the dosing duration utilized in the study.

Topical Endoxifen crossed the skin barrier when applied daily to the breast, as demonstrated by low but measurable Endoxifen blood levels detected in a dose-dependent fashion. Microcatheter Technology We are developing our patented microcatheter technology to deliver therapeutics through the nipple directly to the site of the cancer.

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Home Table of Contents Overview Map. These are my favorite links to research sheet music, literature and biographies. The Classical Music Archives, the largest archive of its kind on the web, offers tens of thousands of classical music files in MIDI, Windows Casino euro best ndb online casino blog MP3 format you can listen to at the click of your mouse.

Most composers are represented - with biographies and timelines. A major award-winning cultural site which provides its own indexes and search engines by keywords or composer. Welcome to the Mutopia Project Download it, print it out, and share it. All music is available as Postscript.

Audio previews of the music are available as MIDI. Welcome to Project GutenbergProject Gutenberg is the oldest producer of free electronic books e- Books or e- texts on the Internet. Best ndb online casino blog collection of more than Most of the Project Gutenberg eBooks are older literary works that are in the public domain in the United States.

All may be freely downloaded and read, and redistributed for non-commercial use. Project Gutenberg volunteers have been engaging in digitizing public domain sheet musicusing a variety of techniques, to enable study and performance. For the most part, the musical pieces created have been chamber music, with composers such as Brahms and Beethoven. The archive contains "free" sheet music, free for non- commercial usage.

This means that best ndb online casino blog may download the files and print paper copies, but neither the files nor the paper copies may be sold. Welcome to Wikipediaa free- content encyclopedia in many languages. In this English edition, started in Januarywe are working on articles.

In addition to typical encyclopedia entries, Wikipedia includes information best ndb online casino blog often associated with almanacsgazetteers, and specialist magazines; and coverage of current events. Great for practicing reading notes, intervalls, Sheet Music USA - great music theory and some songs and links. Limited to 2 downloads a day, great selection.

You can listen and print these scores available in postscript and pdf. Mfiles - Jim Paterson's online archive of sheet music typeset best ndb online casino blog Sibelius. Scores available in pdf and in the Scorch previewing format available for macintosh and windows only. Piano - free piano sheet music - A number of sheet music from movies and popular artists, try this see more too.

Celtic Midi files Music to listen to while you read Celtic folklore at the www. Our books are made by best ndb online casino blog, for musicians and are designed to be the most informative and comprehensive books ever published on their respective topics.

All books are sold with a money-back guarantee for individual customersand with normal trade terms for retail outlets and distributors. The Choral Public Domain Library - a large archive of free choral music. Best ndb online casino blog Tufvesson's free sheet music archive Library - instrumental music from the 17th and 18th century typeset with PMX.

Scores are available in postscript and pdf format. Soloists's free sheet music archive Library - vocal music from the 10th - 20th century typeset with MusiXTeX. The scores are available in postscript format packed in zip files with accompanying typesetting source files. Acadia Early Music Archive - Gordon Callons archive of instrumental and vocal music from renaissance and baroque, typeset rollover definition Score and Sibelius.

Scores are available in postscript format. Project Runeberg, music section - elder Swedish music. Scores available in postscript and pdf format typeset with PMXaccompanied by source files. Scores typeset with Magix Notation and Finale Allegro. Finale source files available on request for a modest fee. Peter Billam's free sheet note archive of compositions and arrangements - typeset with his own music typesetting program muscript. Scores are available in pdf format.

The Recorder Player's Page containing sheet note recorder music by a couple of more info and arrangers. Scores typeset with diffent programs and available in postscript, pdf and gif format. Alain Naigeon's renaissance music web site - including renaissance music scores suitable for recorders, typeset with Encore.

Scores available in pdf format, most of them typeset with Finalea few of them with source file. Coppini Edition - contrafacta of secular music from Monteverdi and other composers, edited and typeset with Finale by Jens Peter Jacobsen.

The scores, typeset with Learn more here and NotePadare available in pdf format. Tablatures pour luths, guitarres, theorbes - Alain Veylit's archive of music for plucked string instruments typeset with his own programs Django and Stringwalker.

T he collection contains tablatures of primarily early music, ao. The scores, some of them with additional note staves, are available in pdf format and are accompanied by source- and MIDI files. There are tablatures as well as note notated music. The scores are available as postscript packed in zip files. The Sheet Music Archive - John Mamoun's archive of free piano music scores, some of them scanned in from public domain prints, other computer typeset.

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